Gastrointestinal System

{"ops":[{"insert":"Diagnosis and reasoning"},{"insert":"\n","attributes":{"header":1}},{"insert":"This infant has presented with prolonged jaundice\u2014a very common clinical scenario. In the vast majority of newborns, this is physiological in origin (due to causes such as breast milk jaundice). However, physiological jaundice typically manifests around 3 to 5 days following birth and usually disappears by 2 weeks of age. Physiological jaundice at 5 weeks of age would be unusual. Therefore, she requires further evaluation.\n\nWhile the history of normal appetite and growth initially appears reassuring, examination reveals an alarming finding: hepatosplenomegaly. This is highly suggestive of cholestatic jaundice, with the most likely etiologies being bile duct abnormalities (such as biliary atresia or a choledochal cyst), inherited causes ("}]}

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