Renal & Urinary System

{"ops":[{"insert":"Diagnosis and reasoning"},{"insert":"\n","attributes":{"header":1}},{"insert":"This HIV positive middle-aged man has presented with dark urine, myalgia, and generalized muscle weakness; note that this is the classic triad of rhabdomyolysis.\n\nAssessment of serum creatine phosphokinase (CPK) and myoglobin levels is a good next step; both are markedly elevated, confirming the clinical diagnosis.\n\nThe question now is - what might have caused the rhabdomyolysis?\n\nWhile diverse etiologies ranging from trauma to drugs, toxins, metabolic derangements and endocrinopathies can give rise to rhabdomyolysis, this patient\u0027s history provides us with a clue towards the likely etiology.\n\nNote that he was recently started on a statin, a class of drugs which are well known to cause rhabdomyolysis.\n\nFurthermore, he is on therapy with a p"}]}

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