Compromised

Immune System


{"ops":[{"insert":"Diagnosis and reasoning"},{"insert":"\n","attributes":{"header":1}},{"insert":"This lady has presented with subacute dyspnea in a background of metastatic malignancy and recent chemotherapy.\n\nThe differential diagnosis is wide and includes complications of the malignancy, such as pulmonary secondaries causing a pleural effusion; as well as complications of chemotherapy, such as heart failure due to cardiotoxicity, anemia due to bone marrow suppression, respiratory infections secondary to impaired immunity, diffuse alveolar haemorrhage (DAH) due to drug-induced thrombocytopenia or coagulopathy, and lung fibrosis.\n\nHowever, note her marked response to oxygen. This hints at a ventilation perfusion (V\/P) defect, narrowing down the likely diagnoses to infection, DAH, and lung fibrosis.\n\nNote also that she is very likely im"}]}

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