Renal & Urinary System

{"ops":[{"insert":"Diagnosis and reasoning"},{"insert":"\n","attributes":{"header":1}},{"insert":"This young man, who happens to be a recent renal transplant recipient, has demonstrated progressively worsening serum creatinine (SCr) levels over time; while at a first glance, the absolute elevation appears to be low, note that this represents a ~50% increase from the preceding month.\n \nAlthough SCr has many limitations with respect to estimating the glomerular filtration rate (GFR), any unexplained elevation should be assumed to indicate declining filtration capability of the graft, thus warranting a prompt evaluation for potential etiologies.\n \nAt first, common causes of a reversible decline in GFR should be considered and excluded; these include dehydration, infections, and urinary obstruction. In this respect, the patient is not dehyd"}]}

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