Mirizzi Syndrome


Step 1: View clinicals

A 48 year old man presents with worsening pain in the upper abdomen for 1 week, in a background of yellowish discoloration of the eyes and intermittent dark urine for 2 months. Close questioning reveals no history of similar episodes in the past, or of other medical or surgical diseases. However, he confesses that he postponed seeking medical attention until now, as he was 'scared that he might have a serious illness'. He has never smoked, and only drinks socially. There is no history of sexual promiscuity, blood transfusions, or intravenous drug abuse. A complete blood count is only significant for a leukocytosis of 11,000/mm3. A renal profile is within normal parameters, as are serum amylase and lipase levels.

Step 2: Order all relevant investigations

Liver Profile

AST: 208 IU/L (10 - 34) ALT: 142 IU/L (10 - 40) ALP: 612 IU/L (44 - 147) Total Bilirubin: 10.1 mg/dL (0.3 - 1.9) Direct Bilirubin: 8.3 mg/dL (0 - 0.3) INR: 1.1 (0.9 - 1.1)

X-Ray Abdomen

The plain radiograph of the abdomen appears completely normal.

Ultrasound Abdomen

The gallbladder is contracted, with multiple calculi. The common hepatic duct and proximal biliary tree are dilated, although the common bile duct is normal in diameter. There is no pneumobilia, and the liver and pancreas appear normal.


There are multiple gallstones impacted in Hartmann's pouch and the cystic duct, which appear to be compressing the common hepatic duct. There is associated dilation of the hepatic duct and intrahepatic biliary tree. There is no evidence of cholecysto-biliary or cholecysto-enteric fistula formation.

Step 3: Select appropriate management

ERCP with Stenting
Ursodeoxycholic Acid

Score: ★★☆