A 23 year old nulliparous woman presents with amenorrhea associated with a weight gain of 12 kg, over a period of 6 months. She attained menarche at age 11, and her menstrual cycles have been irregular since then. She is sexually active and uses barrier methods for contraception. Her family history is significant for type 2 diabetes mellitus in both parents. A urine hCG test is found to be negative.
LH:FSH ratio: 3:1 S. Testosterone: 2.7 nmol/L (reference range <2.1 nmol/L) Low-dose dexamethasone suppression test: negative TSH, 17 hydroxyprogesterone, DHEAS, prolactin: normal
Fasting level: 115 mg/dL At 2 hours: 155 mg/dL
There are between 12 to 15 cysts of 3 to 6 mm in size in the periphery of each ovary. The endometrium is of normal thickness.
Total cholesterol: 184 mg/dL (optimal <200) LDL: 100 mg/dL (optimal <100) HDL: 60 mg/dL (optimal >60) Triglycerides: 120 mg/dL (normal <150)