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Infective Endocarditis


Step 1: View clinicals

A 58 year old man complains of fever for 3 weeks associated with fatigue and lassitude. He is otherwise asymptomatic and has an unremarkable medical history. He has never undergone any surgical or dental procedures and denies recreational drug use. There is no family history of malignancy. A chest x-ray and urinalysis are found to be normal.

Step 2: Order all relevant investigations

Full Blood Count

WBC/DC: 15,000/mm3 N: 82%, L: 13 % Hb: 10.2 g/dl MCV: 70 fl (low) MCH: 25 pg (low) Platelets: 430,000/mm3 Blood Film: Microcytic hypochromic anemia

Blood cultures

The preliminary culture report shows Gram +ve cocci in two samples. The definitive report shows isolation of Streptococcus bovis.


The echocardiogram shows an oscillatory mass attached to the mitral valve with concomitant mitral regurgitation. There are no other structural cardiac defects. The left ventricular ejection fraction (LVEF) is 63%.


Colonoscopy shows an ulcerated fungating growth in the sigmoid colon. Multiple biopsies are sent for histology.

Step 3: Select appropriate management

IV Antibiotics
Anti-Tuberculous therapy
GI Surgical referral

Score: ★★☆