Immune System

{"ops":[{"insert":"Acyclovir: therapy in pregnancy"},{"insert":"\n","attributes":{"header":1}},{"insert":"The use of acyclovir to treat varicella or herpes zoster during pregnancy is recommended only when benefits outweigh risks, as there are no controlled data on teratogenicity in humans. Note that certain nonstandard studies have shown the drug to be teratogenic in animals.\n\nThe Centers for Disease Control and prevention (CDC) recommend use of the drug only in pregnant women with severe or life-threatening disease, i.e. varicella pneumonitis, or herpes zoster encephalitis or hepatitis.\n\nNote in particular that acyclovir should not be used for post-exposure prophylaxis during pregnancy.\n"},{"insert":"Herpes zoster: management"},{"insert":"\n","attributes":{"header":1}},{"insert":"Oral acyclovir and close outpatient followup is sufficient to treat localized herpes zoster.\n\nIntravenous therapy should be reserved for patients with disseminated disease or ophthalmic involvement, or if they are unable to take oral medications.\n"}]}

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