Blood & Lymphoreticular System

{"ops":[{"insert":"Sickle cell disease"},{"insert":"\n","attributes":{"header":1}},{"insert":"Sickle cell disease is a group of disorders with variable pathological alterations of the hemoglobin molecule that lead to chronic hemolytic anemia and vaso-occlusive crises.\r\n\r\nIt is the most common single-gene disorder in African-Americans in the United States, occurring in approximately 1 in 375 individuals. In Sub-Saharan Africa, as many as 33% of adults are carriers and 1-2% of newborns positive for sickle cell disease. \r\n\r\nPatients with sickle cell disease may develop hemolytic anemia and vaso-occlusive crises owing to the morphology of the sickled cells. Timely admission and adequate management can prevent these complications that affect multiple organ systems and potentially avert a variety of pain crises and life-threatening situat"}]}

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