Inherited

Blood & Lymphoreticular System


{"ops":[{"insert":"Beta thalassemia: overview"},{"insert":"\n","attributes":{"header":2}},{"insert":"The thalassemias are a group of autosomal recessive hematologic disorders where decreased or absent synthesis of alpha or beta globin chains leads to lifelong hemolytic anemia. The term \u0022beta thalassemia\u0022 is used when the beta globin chain is affected; this is mainly encountered in persons of Mediterranean, African, and Southeast Asian origin, although all racial groups may be affected. \n\nSynthesis of beta globin chains is regulated by the HBB gene on chromosome 11. Each individual receives a single copy of the gene from either parent. When both copies of the gene are defective, the affected person develops either beta thalassemia major or beta thalassemia intermedia; the difference between the two is in the degree of symptoms. When only a "}]}

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