Complex

Nervous System & Special Senses


{"ops":[{"insert":"Neurofibromatosis (NF)"},{"insert":"\n","attributes":{"header":1}},{"insert":"Neurofibromatosis is a group of congenital disorders affecting the neural tissue. There are two subtypes: type 1, also known as Von Recklinghausen\u0027\u0027s disease, and Type 2. \r\n\r\nNeurofibromatosis type 1 (NF-1) accounts for the vast majority (90%) of cases and affects approximately 1 in 3,000 births. No known racial or sexual predilection exists.\n"},{"insert":"Van Recklinghausen\u0027s disease (NF-1)"},{"insert":"\n","attributes":{"header":1}},{"insert":"NF-1, or Von Recklinghausen\u0027s disease, is the most common variant of neurofibromatosis, comprising approximately 90% of cases. It is inherited in an autosomal dominant pattern, although up to half of cases may be sporadic.\r\n\r\nNF-1 is caused by mutations of the tumor suppressing NF-1 gene located at 17q11.2, leading to cell proliferation throughout the nervous system. \r\n\r\nThe disease begins before the differentiation of the neural crest during embryologic development, and continues after birth, most notably during growth, puberty, and pregnancy.\n"}]}

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