Under Pressure

Multisystem Processes & Disorders

{"ops":[{"insert":"Diagnosing and Treating Suspected Opioid Overdose"},{"insert":"\n","attributes":{"header":1}},{"insert":"Opioid analgesic overdose encompasses a range of clinical findings; these range from the classical toxidrome of apnea, stupor, and miosis, to respiratory depression alone.\n\nAt the bedside, the most easily recognized abnormality is a decline in the respiratory rate (RR), potentially culminating in apnea.\n\nNote in particular that a RR of 12 cycles per minute or less in a patient who is not in physiologic sleep strongly suggests acute opioid intoxication, particularly when accompanied by miosis or stupor.\n\nIt should be appreciated that the absence of miosis does not exclude opioid intoxication; normally reactive or mydriatic pupils can occur in poisoning secondary to meperidine, propoxyphene, and tramadol, and following polysubstance ingestio"}]}

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