Preterm Premature Rupture of Membranes

Ahead of Time


An expectant mother with prematurely ruptured membranes. Will you admit her to the hospital? What will do you if chorioamnionitis develops?

  1. Chorioamnionitis: postpartum antibiotics
  2. Clinical chorioamnionitis: mode of delivery
  3. Epidural Fever or Chorioamnionitis?
  4. Intrapartum fever in the presence of epidural analgesia
  5. PPROM: Inpatient vs Outpatient management
  6. PROM: high vaginal swabs
  7. Subclinical Chorioamnionitis
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  2. BLENCOWE H, COUSENS S, CHOU D, OESTERGAARD M,et al. Born Too Soon: The global epidemiology of 15 million preterm births. Reproductive Health. 2013, vol. 10, Suppl 1, S2-. DOI: 10.1186/1742-4755-10-S1-S2.
  3. CZIKK MJ, MCCARTHY FP , MURPHY KE. Chorioamnionitis: from pathogenesis to treatment. Clinical Microbiology and Infection. 2011, vol. 32, issue 2, no-no. DOI: 10.1111/j.1469-0691.2011.03574.x.
  4. EDWARDS RK, ANDREWS WW. Chorioamnionitis and Labor. Obstetrics and Gynecology Clinics of North America. 2005, vol. 32, issue 2, s. 287-296. DOI: 10.1016/j.ogc.2004.12.002.
  5. EDWARDS RK, DUFF P. Single Additional Dose Postpartum Therapy for Women With Chorioamnionitis. Obstet Gynecol. 2003 Nov;102(5 Pt 1):957-61 Available from
  6. GOETZL L, COHEN A, FRIGOLETTO F, LANG JM, et al. Maternal Epidural Analgesia and Rates of Maternal Antibiotic Treatment in a Low-risk Nulliparous Population: The global epidemiology of 15 million preterm births. Journal of Perinatology. 2003, vol. 23, issue 6, s. 457-461. DOI: 10.1038/
  7. GREENBERG, Mara B., Britta L. ANDERSON, Jay SCHULKIN, Mary E. NORTON a Natali AZIZ. A First Look at Chorioamnionitis Management Practice Variation among US Obstetricians. Infectious Diseases in Obstetrics and Gynecology. 2012, vol. 2012, s. 1-9. DOI: 10.1155/2012/628362.
  8. HORVATH B, LAKATOS F, TÓTH C, BÖDECS T, et al. Silent chorioamnionitis and associated pregnancy outcomes: a review of clinical data gathered over a 16-year period. Journal of Perinatal Medicine. 2014-01-14, vol. 0, issue 0, s. 1-7. DOI: 10.1515/jpm-2013-0186.
  9. MIYAZAKI K, FURUHASHI M,MATSUO K, MINAMI K, et al. Impact of subclinical chorioamnionitis on maternal and neonatal outcomes. Acta Obstetricia et Gynecologica Scandinavica. 2007, vol. 86, issue 2, s. 191-197. DOI: 10.1080/00016340601022793.
  10. Premature rupture of membranes. Practice Bulletin No. 139. American College of Obstetricians and Gynecologists. Obstet Gynecol 2013; 122:918-30. DOI - 10.1097/01.AOG.0000435415.21944.8f
  11. Preterm Prelabour Rupture of Membranes. Green-top Guideline No.44. November 2006. (Minor amendment October 2010). Royal College of Obstetricians and Gynaecologists.
  12. SHARMA SK, ROGERS BB, ALEXANDER JM, MCINTIRE DD,et al. A Randomized Trial of the Effects of Antibiotic Prophylaxis on Epidural-Related Fever in Labor: Taking the Heat.Anesthesia. 2014, vol. 118, issue 3, s. 604-610. DOI: 10.1213/ANE.0b013e3182a5d539.
  13. SHATKEN S, GREENOUGH K, MCPHERSON C, LANG JM, et al. Epidural Fever and Its Implications for Mothers and Neonates: Taking the Heat. Journal of Midwifery. 2012, vol. 57, issue 1, s. 82-85. DOI: 10.1111/j.1542-2011.2011.00105.x.
  14. TITA, ATN, ANDREWS WW. Diagnosis and Management of Clinical Chorioamnionitis. Clinics in Perinatology. 2010, vol. 37, issue 2, s. 339-354. DOI: 10.1016/j.clp.2010.02.003.
  15. VALLEJO MC, KAUL B, ADLER LJ, PHELPS AL, CRAVEN CM, MACPHERSON TA, SWEET RL, RAMANATHAN S. Chorioamnionitis, not epidural analgesia, is associated with maternal fever during labour. Can J Anaesth [online] 2001 Dec, 48(11):1122-6 [viewed 8 May 2014] Available from: doi:10.1007/BF03020380