Immune Thrombocytopenia



Hematological conditions are notoriously tricky to manage during pregnancy. Are you competent enough to ensure the best possible outcome for both mother and fetus?

  1. Anti-D Immunoglobulin therapy in the pregnant patient with ITP
  2. Bone Marrow Studies in acute ITP
  3. Cesarean Section in the pregnant patient with ITP
  4. Effect on Subsequent Pregnancies
  5. Fetal Blood Sampling in ITP
  6. Following up the pregnant patient with ITP
  7. Immune Thrombocytopenic Purpura (ITP)
  8. Investigating the pregnant patient with suspected ITP
  9. Management of ITP in pregnancy
  10. Management of a neonate born to a mother with ITP
  11. Postpartum Thromboprophylaxis in women with ITP
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  2. BECK R. Perinatal and neonatal aspects of maternal idiopathic thrombocytopenic purpura. Am J Perinatol [online] 1984 Apr, 1(3):251-8 [viewed 23 January 2015] Available from: doi:10.1055/s-2007-1000014
  3. BHASIN TS, SHARMA S, MANJARI M, MANNAN R, KANSAL V, CHANDEY M, PIPLANI S. Changes in megakaryocytes in cases of thrombocytopenia: bone marrow aspiration and biopsy analysis. J Clin Diagn Res [online] 2013 Mar, 7(3):473-9 [viewed 23 January 2015] Available from: doi:10.7860/JCDR/2013/5085.2801
  4. CINES DB, BLANCHETTE VS. Immune thrombocytopenic purpura. N Engl J Med [online] 2002 Mar 28, 346(13):995-1008 [viewed 05 February 2015] Available from: doi:10.1056/NEJMra010501
  5. COOK RL, MILLER RC, KATZ VL, CEFALO RC. Immune thrombocytopenic purpura in pregnancy: a reappraisal of management. Obstet Gynecol [online] 1991 Oct, 78(4):578-83 [viewed 05 February 2015] Available from:
  6. DUBBELD P, VAN DER HEUL C, HILLEN HF. Effect of high-dose dexamethasone in prednisone-resistant autoimmune thrombocytopenic purpura (ITP). Neth J Med [online] 1991 Aug, 39(1-2):6-10 [viewed 23 January 2015] Available from:
  7. GERNSHEIMER T., JAMES A. H., STASI R.. How I treat thrombocytopenia in pregnancy. Blood [online] December, 121(1):38-47 [viewed 14 February 2015] Available from: doi:10.1182/blood-2012-08-448944
  8. GOPINATH R, SREEKANTH Y, YADAV M. Approach to bleeding patient. Indian J Anaesth [online] 2014 Sep, 58(5):596-602 [viewed 23 January 2015] Available from: doi:10.4103/0019-5049.144664
  9. HACHISUGA K, HIDAKA N, FUJITA Y, FUKUSHIMA K, KATO K. Can we predict neonatal thrombocytopenia in offspring of women with idiopathic thrombocytopenic purpura? Blood Res [online] 2014 Dec, 49(4):259-64 [viewed 05 February 2015] Available from: doi:10.5045/br.2014.49.4.259
  10. JUBELIRER SJ, HARPOLD R. The role of the bone marrow examination in the diagnosis of immune thrombocytopenic purpura: case series and literature review. Clin Appl Thromb Hemost [online] 2002 Jan, 8(1):73-6 [viewed 05 February 2015] Available from:
  11. NEUNERT C, LIM W, CROWTHER M, COHEN A, SOLBERG L JR, CROWTHER MA, AMERICAN SOCIETY OF HEMATOLOGY. The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood [online] 2011 Apr 21, 117(16):4190-207 [viewed 17 February 2015] Available from: doi:10.1182/blood-2010-08-302984
  12. PROVAN D, STASI R, NEWLAND AC, BLANCHETTE VS, BOLTON-MAGGS P, BUSSEL JB, CHONG BH, CINES DB, GERNSHEIMER TB, GODEAU B, GRAINGER J, GREER I, HUNT BJ, IMBACH PA, LYONS G, MCMILLAN R, RODEGHIERO F, SANZ MA, TARANTINO M, WATSON S, YOUNG J, KUTER DJ. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood [online] 2010 Jan 14, 115(2):168-86 [viewed 17 February 2015] Available from: doi:10.1182/blood-2009-06-225565
  13. RADAELLI F, FACCINI P, GOLDANIGA M, GUGGIARI E, POZZOLI E, MAIOLO AT, CIANI A, POGLIANI EM. Factors predicting response to splenectomy in adult patients with idiopathic thrombocytopenic purpura. Haematologica [online] 2000 Oct, 85(10):1040-4 [viewed 23 January 2015] Available from:
  14. RODEGHIERO F, STASI R, GERNSHEIMER T, MICHEL M, PROVAN D, ARNOLD DM, BUSSEL JB, CINES DB, CHONG BH, COOPER N, GODEAU B, LECHNER K, MAZZUCCONI MG, MCMILLAN R, SANZ MA, IMBACH P, BLANCHETTE V, K├╝HNE T, RUGGERI M, GEORGE JN. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood [online] 2009 Mar 12, 113(11):2386-93 [viewed 05 February 2015] Available from: doi:10.1182/blood-2008-07-162503
  15. SAILER T, LECHNER K, PANZER S, KYRLE PA, PABINGER I. The course of severe autoimmune thrombocytopenia in patients not undergoing splenectomy. Haematologica [online] 2006 Aug, 91(8):1041-5 [viewed 23 January 2015] Available from:
  16. SCHIPPERUS M, FIJNHEER R. New therapeutic options for immune thrombocytopenia. Neth J Med [online] 2011 Nov-Dec, 69(11):480-5 [viewed 17 February 2015] Available from:
  17. SHARAMI SH, FARAJI DARKHANEH R, ZAHIRI Z, MILANI F, ASGHARNIA M, SHAKIBA M, DIDAR Z. The relationship between vaginal bleeding in the first and second trimester of pregnancy and preterm labor. Iran J Reprod Med [online] 2013 May, 11(5):385-90 [viewed 23 January 2015] Available from:
  18. TOWNSLEY DM. Hematologic Complications of Pregnancy Semin Hematol [online] 2013 Jul, 50(3):222-231 [viewed 17 February 2015] Available from: doi:10.1053/j.seminhematol.2013.06.004
  19. VAN DER LUGT NM, VAN KAMPEN A, WALTHER FJ, BRAND A, LOPRIORE E. Outcome and management in neonatal thrombocytopenia due to maternal idiopathic thrombocytopenic purpura. Vox Sang [online] 2013 Oct, 105(3):236-43 [viewed 23 January 2015] Available from: doi:10.1111/vox.12036
  20. WEBERT KE, MITTAL R, SIGOUIN C, HEDDLE NM, KELTON JG. A retrospective 11-year analysis of obstetric patients with idiopathic thrombocytopenic purpura. Blood [online] 2003 Dec 15, 102(13):4306-11 [viewed 05 February 2015] Available from: doi:10.1182/blood-2002-10-3317
  21. YUCE T, ACAR D, KALAFAT E, ALKILIC A, CETINDAG E, SOYLEMEZ F. Thrombocytopenia in pregnancy: do the time of diagnosis and delivery route affect pregnancy outcome in parturients with idiopathic thrombocytopenic purpura? Int J Hematol [online] 2014 Dec, 100(6):540-4 [viewed 05 February 2015] Available from: doi:10.1007/s12185-014-1688-6